quantitative cell biology
We are interested in the strategies that cells use to control gene expression levels and variability during differentiation. The links between the dynamic nuclear structures and transcriptional changes are a focus of our lab. The compartmentalization of the nucleus into several functional condensates, so-called membrane-less organelles, contributes to transcriptional regulation. We study how different compartments in the nucleus spatially organize the genome and how this impacts gene expression throughout development.
We develop cutting-edge quantitative methods for single-cell genomics and combine them with cellular phenotyping using high-content confocal microscopy. We design data-driven approaches, we build quantitative predictive models and use state-of-the-art machine-learning to gain insights into the cellular processes we study.